Ventrolateral periaqueductal gray neurons prioritize threat probability over fear output
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منابع مشابه
When fear is near: threat imminence elicits prefrontal-periaqueductal gray shifts in humans.
Humans, like other animals, alter their behavior depending on whether a threat is close or distant. We investigated spatial imminence of threat by developing an active avoidance paradigm in which volunteers were pursued through a maze by a virtual predator endowed with an ability to chase, capture, and inflict pain. Using functional magnetic resonance imaging, we found that as the virtual preda...
متن کاملMobbs , Prefrontal - Periaqueductal Gray Shifts in Humans When Fear Is Near : Threat Imminence Elicits
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متن کاملPrefrontal - Periaqueductal Gray Shifts in Humans When Fear Is Near : Threat Imminence Elicits
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The periaqueductal gray (PAG) modulates nociception via a descending pathway that relays in the rostral ventromedial medulla (RVM) and terminates in the spinal cord. Previous behavioral pharmacology and electrophysiological evidence suggests that brain-derived neurotrophic factor (BDNF) plays an important role in descending pain modulation, likely through the PAG-RVM pathway. However, detailed ...
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Freezing, a characteristic pattern of defensive behavior elicited by fear, is associated with a decrease in the heart rate. Central mechanisms underlying fear bradycardia are poorly understood. The periaqueductal gray (PAG) in the midbrain is known to contribute to autonomic cardiovascular adjustments associated with various emotional behaviors observed during active or passive defense reaction...
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ژورنال
عنوان ژورنال: eLife
سال: 2019
ISSN: 2050-084X
DOI: 10.7554/elife.45013